January 1, 2006Hypertension ResearchOpen Access

The Effects of Changes in the Metabolic Syndrome Detection Status on Arterial Stiffening: A Prospective Study

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Why the study?

Does persistent metabolic syndrome accelerate the progression of arterial stiffness in middle-aged Japanese men?

Population

2,080 Japanese male employees of a single large construction company, mean age 42 +/- 9 years. Key…

Comparison

Persistent metabolic syndrome or newly detected… vs Absence of metabolic syndrome or regression of…

Design

Cohort

Follow-up

3 years

Authors

HTHirofumi TomiyamaPreventive Cardiology YHYoji HirayamaHashimoto Municipal Hospital HHHideki HashimotoJichi Medical University

Discussion

Member takes

Implication

Persistent metabolic syndrome was associated with faster arterial stiffening; hypothesis-generating and requires prospective trials before guiding care.

Structured PICO

Does persistent metabolic syndrome accelerate the progression of arterial stiffness in middle-aged Japanese men?

Population

2,080 Japanese male employees of a single large construction company, mean age 42 +/- 9 years. Key exclusions: ankle/brachial systolic blood pressure index (ABI) < 0.95, atrial fibrillation, regular hemodialysis, or receiving medication for hypertension, dyslipidemia, diabetes mellitus, heart disease, and/or stroke.

Intervention

Persistent metabolic syndrome or newly detected metabolic syndrome over a 3-year period.

Comparator

Absence of metabolic syndrome or regression of metabolic syndrome over a 3-year period.

Outcome

Annual rate of progression of arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV) over a 3-year period.surrogate

Persistent metabolic syndrome accelerates arterial stiffening in middle-aged men, whereas its resolution attenuates this progression, highlighting the importance of early intervention.

Limitations

Central arterial stiffness (e.g., carotid-femoral PWV) is a more robust marker than peripheral arterial stiffness (baPWV).
Subjects were restricted to Japanese men, requiring further studies in women.
BMI was used instead of waist circumference for the definition of metabolic syndrome, which is not a robust marker of central obesity.

Cite This Study

Tomiyama et al. (2006) studied this question.

synapsesocial.com/papers/6a760ca0fa1990f79e613b41 https://doi.org/10.1291/hypres.29.673

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Implication

Persistent metabolic syndrome was associated with faster arterial stiffening; hypothesis-generating and requires prospective trials before guiding care.

The Effects of Changes in the Metabolic Syndrome Detection Status on Arterial Stiffening: A Prospective Study

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The Effects of Changes in the Metabolic Syndrome Detection Status on Arterial Stiffening: A Prospective Study

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider