September 1, 2005Pacing and Clinical Electrophysiology
Rapid Decline in Acute Stimulation Thresholds with Steroid‐Eluting Active‐Fixation Pacing Leads
Key result
Active-fixation pacing leads frequently exhibit initial high stimulation thresholds (>1 V) that decline rapidly within 4 minutes (P<0.01), indicating lead repositioning can often be avoided.
Why the study?
Do initial high stimulation thresholds of steroid-eluting active-fixation pacing leads decline rapidly after implantation in patients receiving new pacemakers?
Population
94 patients undergoing implantation of 79 dual-chamber and 15 single-chamber pacemakers using…
Design
Cohort
Follow-up
8 weeks
Authors
Discussion
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Implication
May support provisional acceptance of thresholds ≤2 V with 4-min retesting before repositioning; hypothesis-generating and requires randomized confirmation.
Study Design
Type
Observational (n=94)
Structured PICO
Do initial high stimulation thresholds of steroid-eluting active-fixation pacing leads decline rapidly after implantation in patients receiving new pacemakers?
P
Population
94 patients undergoing implantation of 79 dual-chamber and 15 single-chamber pacemakers using active-fixation leads in both chambers
I
Intervention
Steroid-eluting active-fixation pacing leads
O
Outcome
Pacing parameters (stimulation thresholds) measured at 2-minute intervals for 10 minutes, and at day 1 and week 8 following implantsurrogate
Main Result
p-value: p=<0.01
Initial high stimulation thresholds of active-fixation pacing leads decline rapidly within minutes, suggesting that an initial threshold up to 2 V can be provisionally accepted and retested at 4 minutes before considering lead repositioning.
Cite This Study
Kistler et al. (2005) conducted an observational in Pacemaker implantation (n=94). Steroid-eluting active-fixation pacing leads was evaluated on Pacing parameters (stimulation thresholds) at 2-minute intervals for 10 minutes, day 1, and week 8 (p=<0.01). Active-fixation pacing leads frequently exhibit initial high stimulation thresholds (>1 V) that decline rapidly within 4 minutes (P<0.01), indicating lead repositioning can often be avoided.