Key result
The minor G allele of the SGK1 gene variant rs9402571 was associated with increased insulin secretion in lean non-diabetic individuals and a lower prevalence of type 2 diabetes (OR 0.85).
Why the study?
Does the SGK1 rs9402571 minor G allele improve insulin secretion and reduce the prevalence of type 2 diabetes in European populations?
Population
6,009 individuals from three independent European cohorts: TUEF, EUGENE2, and METSIM.
Comparison
SGK1 gene variations, specifically the rs9402571… vs Homozygous wild type TT carriers
Design
Cohort
Authors
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No immediate change to T2D risk assessment; leaves open causal effects and needs prospective validation in broader populations.
Observational (n=6,009)
Yes
Does the SGK1 rs9402571 minor G allele improve insulin secretion and reduce the prevalence of type 2 diabetes in European populations?
Effect estimate: OR 0.85 (95% CI 0.71-1.01)
p-value: p=0.065
The SGK1 rs9402571 minor G allele is associated with increased insulin secretion in lean individuals and may confer a protective effect against type 2 diabetes.
Friedrich et al. (2008) conducted an observational in Type 2 Diabetes Mellitus (n=6,009). SGK1 gene variant rs9402571 minor G allele vs. Homozygous wild type TT carriers was evaluated on Prevalence of type 2 diabetes (METSIM cohort) (OR 0.85, 95% CI 0.71-1.01, p=0.065). The minor G allele of the SGK1 gene variant rs9402571 was associated with increased insulin secretion in lean non-diabetic individuals and a lower prevalence of type 2 diabetes (OR 0.85).
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