What question did this study set out to answer?

To determine whether 19 common polymorphisms across 14 candidate genes predict the prevalence and 9-year incidence of glucose intolerance and type 2 diabetes in a prospective population cohort.

November 1, 2007Diabetes

Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

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Authors

MVMartine VaxillaireCentre National de la Recherche Scientifique JVJacques VeslotCentre National de la Recherche Scientifique CDChristian DinaDélégation Paris 5

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Implication

Prospective cohort study reveals cumulative genetic variants increase type 2 diabetes risk in middle-aged adults, highlighting the predictive value of combining candidate gene polymorphisms.

Key Points

To determine whether 19 common polymorphisms across 14 candidate genes predict the prevalence and 9-year incidence of glucose intolerance and type 2 diabetes in a prospective population cohort.
Analyzed 19 common candidate gene polymorphisms in 3,877 middle-aged Caucasian participants followed for 9 years in the prospective DESIR study.
Assessed incident hyperglycemia (16.8%) and type 2 diabetes (7.9%), as well as glycemic traits, beta-cell function, and gene-environment interactions.
The GCK -30A allele was associated with incident type 2 diabetes (adjusted OR 1.34 [95% CI 1.07–1.69]), increased fasting glycemia by 0.85% per allele (P = 6 x 10⁻⁵), and reduced beta-cell function by 4% (P = 0.0009).
IL6 -174 G/C interacted with age to alter disease risk and modulated fasting glycemia (1.36% decrease over 56 years, P = 5 x 10⁻⁵).
Accumulating risk alleles across GCK, TCF7L2, and IL6 increased diabetes risk by 1.34 per allele (P = 2 x 10⁻⁶), reaching an OR of 2.48 (95% CI 1.59–3.86) for individuals carrying four or more risk alleles versus zero to one.

Cite This Study

Vaxillaire et al. (2007) studied this question.

synapsesocial.com/papers/6a8af39ba42d46e0ffcaa3ee https://doi.org/10.2337/db07-0615

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Implication

Prospective cohort study reveals cumulative genetic variants increase type 2 diabetes risk in middle-aged adults, highlighting the predictive value of combining candidate gene polymorphisms.

Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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