Key result
The 1273AGA allele of the SUR1 gene was associated with a 2-fold increased risk of conversion from impaired glucose tolerance to type 2 diabetes (OR 2.00; 95% CI 1.19-3.36; P=0.009).
Why the study?
Do polymorphisms in the SUR1 and Kir6.2 genes predict the conversion from impaired glucose tolerance to type 2 diabetes in subjects with impaired glucose tolerance?
Population
490 subjects with impaired glucose tolerance participating in the Finnish Diabetes Prevention Study
Comparison
Presence of polymorphisms in the SUR1 and Kir6.2… vs Absence of these risk genotypes
Design
Cohort
Authors
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SUR1 1273AGA allele may aid risk stratification in impaired glucose tolerance; hypothesis-generating and requires prospective validation before clinical adoption.
Cohort (n=490)
Do polymorphisms in the SUR1 and Kir6.2 genes predict the conversion from impaired glucose tolerance to type 2 diabetes in subjects with impaired glucose tolerance?
Odds Ratio: 2 (95% CI 1.19–3.36)
p-value: p=0.009
Polymorphisms in the SUR1 and Kir6.2 genes additively predict the conversion from impaired glucose tolerance to type 2 diabetes.
Laukkanen et al. (2004) conducted a cohort in Impaired glucose tolerance (n=490). 1273AGA allele of the SUR1 gene vs. Absence of the allele was evaluated on Conversion to type 2 diabetes (OR 2.00, 95% CI 1.19-3.36, p=0.009). The 1273AGA allele of the SUR1 gene was associated with a 2-fold increased risk of conversion from impaired glucose tolerance to type 2 diabetes (OR 2.00; 95% CI 1.19-3.36; P=0.009).
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