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March 1, 1998Diabetes

Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.

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Key result

SUR1 gene mutations impairing K(ATP) channel function do not appear to be major determinants of NIDDM susceptibility in Japanese patients.

Population

100 Japanese patients with NIDDM and 67 nondiabetic control subjects; HEK293T and COS-7 cells for functional…

Comparison

Single strand conformation polymorphism analysis… vs Nondiabetic control subjects and wild-type K…

Design

Preclinical

Authors

YOYasuharu OhtaYamaguchi UniversityYTYukio TanizawaYamaguchi UniversityHIHiroshi InoueTokushima University Hospital

Discussion

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Overview

Does not support SUR1-focused NIDDM screening in Japanese patients; leaves open other genetic contributors for investigation.

Study Design

Type

Case-Control (n=167)

Structured PICO

P
Population
100 Japanese patients with NIDDM and 67 nondiabetic control subjects evaluated for SUR1 gene mutations.
E
Exposure
Single strand conformation polymorphism analysis of the SUR1 gene and functional reconstitution of mutant K(ATP) channels
C
Comparator
Nondiabetic control subjects and wild-type K(ATP) channels
O
Outcome
Presence of SUR1 gene mutations and their functional impact on K(ATP) channel activitiessurrogate

SUR1 mutations that impair K(ATP) channel function are not a major determinant of NIDDM susceptibility in the Japanese population.

Cite This Study

Ohta et al. (1998) conducted a case-control in NIDDM (n=167). SUR1 gene mutations vs. Nondiabetic control subjects was evaluated on Functional alteration of K(ATP) channel activities and NIDDM susceptibility. SUR1 gene mutations impairing K(ATP) channel function do not appear to be major determinants of NIDDM susceptibility in Japanese patients.

synapsesocial.com/papers/6a930af4ce62e2ff0971fba5https://doi.org/10.2337/diabetes.47.3.476
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.1998 · 114 citations
  2. 2Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region2004 · 312 citations
  3. 3Association studies of variants in promoter and coding regions of beta‐cell ATP‐sensitive K‐channel genes <i>SUR1</i> and <i>Kir6.2</i> with Type 2 diabetes mellitus (UKPDS 53)2001 · 173 citations
  4. 4Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: A population study2001 · 42 citations
  5. 5Association of a single nucleotide polymorphism in the SUR1 gene with type 2 diabetes and obesity in Turkish patients2011 · 3 citations