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March 1, 2001Diabetic MedicineOpen Access

Association studies of variants in promoter and coding regions of beta‐cell ATP‐sensitive K‐channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)

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Why the study?

Are genetic variants in SUR1 and Kir6.2 associated with Type 2 diabetes mellitus?

Population

692 subjects from the UKPDS cohort, comprising 364 Type 2 diabetic subjects and 328 normoglycaemic control…

Comparison

Presence of genetic variants in SUR1 and Kir6.2 vs Absence of variants / normoglycaemic control…

Design

Case-control

Authors

AGAnna L. GloynCentre for Human GeneticsYHY HashimHammersmith HospitalSAS. J. H. AshcroftUniversity of Copenhagen

Discussion

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Overview

E23K KK genotype may confer T2DM susceptibility; leaves open causal contribution and generalizability beyond this cohort.

Structured PICO

Are genetic variants in SUR1 and Kir6.2 associated with Type 2 diabetes mellitus?

P
Population
692 subjects from the UKPDS cohort, comprising 364 Type 2 diabetic subjects and 328 normoglycaemic control subjects.
I
Intervention
Presence of genetic variants in SUR1 (exon 16-3t, exon 18 T, promoter variants) and Kir6.2 (E23K)
C
Comparator
Absence of variants / normoglycaemic control subjects
O
Outcome
Association with Type 2 diabetes mellitussurrogate

The E23K variant of Kir6.2 is associated with Type 2 diabetes mellitus in the UKPDS cohort, while SUR1 promoter variants showed no association.

Limitations

  • The minimal promoter region of SUR1 has yet to be investigated.

Cite This Study

Gloyn et al. (2001) studied this question.

synapsesocial.com/papers/6a835f3abe60e97fec18fda7https://doi.org/10.1046/j.1464-5491.2001.00449.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.1998 · 114 citations
  2. 2Amino Acid Polymorphisms in the ATP-Regulatable Inward Rectifier Kir6.2 and Their Relationships to Glucose- and Tolbutamide-Induced Insulin Secretion, the Insulin Sensitivity Index, and NIDDM1997 · 73 citations
  3. 3Genetic Studies of the Sulfonylurea Receptor Gene Locus in NIDDM and in Morbid Obesity Among French Caucasians1997 · 92 citations
  4. 4Sequence Variants in the Sulfonylurea Receptor (SUR) Gene Are Associated With NIDDM in Caucasians1996 · 129 citations
  5. 5Sequence Variants in the Pancreatic Islet β-Cell Inwardly Rectifying K+ Channel Kir6.2 (Bir) Gene: Identification and Lack of Role in Caucasian Patients with NIDDM1997 · 104 citations