March 1, 1997Diabetes
Amino Acid Polymorphisms in the ATP-Regulatable Inward Rectifier Kir6.2 and Their Relationships to Glucose- and Tolbutamide-Induced Insulin Secretion, the Insulin Sensitivity Index, and NIDDM
Key result
Carriers of the maximal load of Kir6.2 amino acid variants had on average a 62% higher insulin sensitivity index compared with noncarriers (P=0.006).
Why the study?
Are Kir6.2 amino acid polymorphisms associated with altered insulin secretion, insulin sensitivity, or NIDDM?
Population
69 Danish NIDDM patients and 66 matched control subjects; plus 346 young healthy subjects for phenotype study
Comparison
Presence of Kir6.2 amino acid polymorphisms vs Noncarriers of Kir6.2 amino acid polymorphisms
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Kir6.2 variant load was associated with higher insulin sensitivity; hypothesis-generating for NIDDM genetics and requires prospective confirmation.
Study Design
Type
Observational (n=481)
Structured PICO
Are Kir6.2 amino acid polymorphisms associated with altered insulin secretion, insulin sensitivity, or NIDDM?
P
Population
481 participants including 69 Danish NIDDM patients, 66 matched controls, and 346 young healthy subjects assessed for Kir6.2 gene mutations and their relationship to insulin secretion and sensitivity.
E
Exposure
Presence of Kir6.2 amino acid polymorphisms (codon 23, 270, 337)
C
Comparator
Noncarriers of Kir6.2 amino acid polymorphisms
O
Outcome
Association with NIDDM, insulin secretion after IV glucose or tolbutamide injections, and insulin sensitivity indexsurrogate
Main Result
p-value: p=0.006
A combination of common Kir6.2 amino acid variants may contribute to the genetic variation of the insulin sensitivity index in the general population.
Cite This Study
Hansen et al. (1997) conducted an observational in NIDDM (n=481). Kir6.2 amino acid polymorphisms vs. Noncarriers was evaluated on Insulin sensitivity index (p=0.006). Carriers of the maximal load of Kir6.2 amino acid variants had on average a 62% higher insulin sensitivity index compared with noncarriers (P=0.006).