What is the clinical evidence from this study?

Study design: Case-Control. Population: Type 2 diabetes and obesity (n=170). Intervention: A allele of the SUR1 gene exon 31 R1273R SNP vs. Healthy controls. Primary outcome: Frequency of the A allele (p=<0.01).

June 14, 2011Journal of Clinical and Experimental InvestigationsOpen Access

Association of a single nucleotide polymorphism in the SUR1 gene with type 2 diabetes and obesity in Turkish patients

Q: What are the key findings of this study?

The frequency of the A allele in exon 31 of the SUR1 gene was significantly higher in type 2 diabetic patients compared to healthy controls (41% vs. 24%, p<0.01), especially in obese patients.

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Key result

The frequency of the A allele in exon 31 of the SUR1 gene was significantly higher in type 2 diabetic patients compared to healthy controls (41% vs. 24%, p<0.01), especially in obese patients.

Why the study?

Is the single nucleotide polymorphism in exon 31 of the SUR1 gene associated with type 2 diabetes and obesity in Turkish patients?

Population

90 Turkish patients with type 2 diabetes and 80 age and sex-matched healthy volunteers without a family…

Comparison

Single nucleotide polymorphism in exon 31 of the… vs Healthy volunteers without a family history of…

Design

Case-control

Authors

OEOsman EvliyaoğluHeidelberg University ESEnver Sancaktar ESErkan SöğütIzmir Atatürk Eğitim ve Araştırma Hastanesi

Discussion

Member takes

Overview

Should not change T2DM management; leaves open causal role of SUR1 variants in obese Turkish patients.

Study Design

Type

Case-Control (n=170)

Structured PICO

Is the single nucleotide polymorphism in exon 31 of the SUR1 gene associated with type 2 diabetes and obesity in Turkish patients?

Population

170 Turkish adults aged 43-70 years, including 90 with type 2 diabetes and 80 healthy controls, evaluated for the association of SUR1 gene exon 31 polymorphism with diabetes and obesity.

Exposure

Single nucleotide polymorphism (SNP) in exon 31 of the SUR1 gene (R1273R)

Comparator

Healthy volunteers without a family history of diabetes

Outcome

Genotype and allele frequency distribution of exon 31 SNP of the SUR1 genesurrogate

Main Result

Absolute Event Rate: 41% vs 24%

p-value: p=<0.01

The SNP in exon 31 of the SUR1 gene is strongly associated with type 2 diabetes mellitus in Turkish patients, particularly those with concomitant obesity.

Limitations

Small sample size
Requires investigation in larger populations to properly evaluate interactions of SUR variants with insulin secretion, sensitivity, and obesity

Cite This Study

Evliyaoğlu et al. (2011) conducted a case-control in Type 2 diabetes and obesity (n=170). A allele of the SUR1 gene exon 31 R1273R SNP vs. Healthy controls was evaluated on Frequency of the A allele (p=<0.01). The frequency of the A allele in exon 31 of the SUR1 gene was significantly higher in type 2 diabetic patients compared to healthy controls (41% vs. 24%, p<0.01), especially in obese patients.

synapsesocial.com/papers/6a930b66c0b3311637eb479b https://doi.org/10.5799/ahinjs.01.2011.02.0232

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June 14, 2011Journal of Clinical and Experimental InvestigationsOpen Access

Association of a single nucleotide polymorphism in the SUR1 gene with type 2 diabetes and obesity in Turkish patients

View Full Paper

Ask AI

Bookmark

Key result

The frequency of the A allele in exon 31 of the SUR1 gene was significantly higher in type 2 diabetic patients compared to healthy controls (41% vs. 24%, p<0.01), especially in obese patients.

Why the study?

Is the single nucleotide polymorphism in exon 31 of the SUR1 gene associated with type 2 diabetes and obesity in Turkish patients?

Population

90 Turkish patients with type 2 diabetes and 80 age and sex-matched healthy volunteers without a family…

Comparison

Single nucleotide polymorphism in exon 31 of the… vs Healthy volunteers without a family history of…

Design

Case-control

Authors

OEOsman EvliyaoğluHeidelberg University ESEnver Sancaktar ESErkan SöğütIzmir Atatürk Eğitim ve Araştırma Hastanesi

Discussion

Member takes

Overview

Should not change T2DM management; leaves open causal role of SUR1 variants in obese Turkish patients.

Study Design

Type

Case-Control (n=170)

Structured PICO

Is the single nucleotide polymorphism in exon 31 of the SUR1 gene associated with type 2 diabetes and obesity in Turkish patients?

Population

170 Turkish adults aged 43-70 years, including 90 with type 2 diabetes and 80 healthy controls, evaluated for the association of SUR1 gene exon 31 polymorphism with diabetes and obesity.

Exposure

Single nucleotide polymorphism (SNP) in exon 31 of the SUR1 gene (R1273R)

Comparator

Healthy volunteers without a family history of diabetes

Outcome

Genotype and allele frequency distribution of exon 31 SNP of the SUR1 genesurrogate

Main Result

Absolute Event Rate: 41% vs 24%

p-value: p=<0.01

The SNP in exon 31 of the SUR1 gene is strongly associated with type 2 diabetes mellitus in Turkish patients, particularly those with concomitant obesity.

Limitations

Small sample size
Requires investigation in larger populations to properly evaluate interactions of SUR variants with insulin secretion, sensitivity, and obesity

Cite This Study

synapsesocial.com/papers/6a930b66c0b3311637eb479b https://doi.org/10.5799/ahinjs.01.2011.02.0232

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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