Key result
Carriers of the SUR1 exon 18 Thr759 T allele had 12.8% lower fasting C-peptide (P=0.022) and 12.4% lower acute C-peptide responses (P=0.051) compared to noncarriers.
Why the study?
Do SUR1 gene sequence variants reduce insulin secretion parameters in nondiabetic subjects?
Population
731 individuals (685 nondiabetic subjects) from the Québec Family Study
Comparison
Presence of SUR1 gene IVS15-3c-->t and exon 18… vs Noncarriers of the respective alleles/haplotypes
Design
Cross-sectional
Authors
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Should not change practice in nondiabetics; leaves open SUR1 variant effects on diabetes risk.
Cross-Sectional (n=731)
Do SUR1 gene sequence variants reduce insulin secretion parameters in nondiabetic subjects?
Effect estimate: -12.8% difference
p-value: p=0.022
Sequence variants in the SUR1 gene are associated with lower insulin secretion parameters in nondiabetic individuals, particularly in female and overweight subjects.
Weisnagel et al. (2001) conducted a cross-sectional in Nondiabetic (n=731). SUR1 gene exon 18 Thr759 T allele and cT/tC haplotype vs. Noncarriers was evaluated on Fasting C-peptide (CPEP) (-12.8% difference, p=0.022). Carriers of the SUR1 exon 18 Thr759 T allele had 12.8% lower fasting C-peptide (P=0.022) and 12.4% lower acute C-peptide responses (P=0.051) compared to noncarriers.
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