Key result
Multi-contrast late enhancement MRI correlated with electro-anatomical voltage mapping for identifying infarct border zone percentage (r=0.74, p<0.0001), though discrepancies existed in subtle infarcts.
Why the study?
Does multi-contrast late enhancement MRI correlate with electro-anatomical voltage mapping for characterizing infarct border zones in a porcine model of chronic MI?
Does multi-contrast late enhancement MRI correlate with electro-anatomical voltage mapping for characterizing infarct border zones in a porcine model of chronic MI?
A novel MRI method (MCLE) correlates significantly with electro-anatomical voltage mapping for identifying the arrhythmogenic border zone in chronic MI, offering a potential non-invasive alternative for substrate characterization.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for non-invasive border zone mapping in chronic MI models; leaves open human validation before clinical use.
The arrhythmogenic substrate in patients with prior myocardial infarct (MI) is located at the border zone, BZ. In this study we correlated the BZ identified by two methods: electro-anatomical voltage mapping (EAVM) and a novel MRI method, multi-contrast late enhancement (MCLE). A pre-clinical porcine model with chronic MI was used to characterize BZ via MRI and EAVM. Results focus on the comparison between scar percentage and BZ percentage identified by each method. The correlation coefficient for BZ percentage between the two methods was 0.74 with a p-value of less the 0.0001. Bland-Altman plots were also used to compare between the two methods (slope of 0.83 ± 0.045). For a case of subtle infarct, there was only 1.3% infarct identified on EAVM compared to 22.2% on the corresponding slice on MCLE. The percentage of infarct on MCLE in subtle infarct does not relate to percentage of infarct in EAVM. Future registration between T(1) maps and EAVM will permit a quantitative comparison of MRI and EAVM measures.
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Shokrollahi et al. (2011) studied Chronic myocardial infarct. Multi-contrast late enhancement (MCLE) MRI vs. Electro-anatomical voltage mapping (EAVM) was evaluated on Correlation of border zone percentage between MCLE and EAVM (Correlation coefficient 0.74, p=<0.0001). Multi-contrast late enhancement MRI correlated with electro-anatomical voltage mapping for identifying infarct border zone percentage (r=0.74, p<0.0001), though discrepancies existed in subtle infarcts.
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