Why the study?
Does right ventricular hypertrophy and failure alter myocardial high energy phosphate stores (ATP and CP) in vivo and in vitro in cats?
Does right ventricular hypertrophy and failure alter myocardial high energy phosphate stores (ATP and CP) in vivo and in vitro in cats?
Depressed contractility in hypertrophied and failing myocardium is not due to an intrinsic reduction in energy stores, but rather an in vivo imbalance between energy production and utilization.
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Contractile dysfunction in RV hypertrophy unlikely from intrinsic ATP depletion; leaves open in vivo energy imbalance as target in human HF.
Pool et al. (1967) studied this question.
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