August 1, 1966Circulation ResearchOpen Access

Myocardial High Energy Phosphate Stores in Acutely Induced Hypoxic Heart Failure

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Population

18 anesthetized dogs

Design

Preclinical

Authors

Discussion

Challenges high-energy phosphate depletion as trigger for hypoxic failure; leaves open translation from animal models to clinical HF.

Population

18 anesthetized dogs

Intervention

Acute hypoxia induction

Outcome

Myocardial concentrations of adenosine triphosphate (ATP) and creatine phosphate (CP) in relation to myocardial functionsurrogate

Hypoxic depression of myocardial function in acute heart failure is not initiated by a decrease in total myocardial high energy phosphate stores.

Cannot exclude that a particular fraction of the high energy phosphate store is decreased when myocardial failure is induced by hypoxia

Pool et al. (1966) studied this question.

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