Key result
Hypoxic perfusion in rat hearts caused a >80% reduction in mechanical activity without significantly decreasing the rate of ATP utilization, suggesting non-contractile processes hydrolyze ATP.
Population
Rat heart model
Comparison
Hypoxic perfusion vs Normoxic perfusion
Design
Preclinical
Authors
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Questions ATP depletion as driver of hypoxic failure in rats; hypothesis-generating for direct PO2 effects on inotropy in humans.
Acute contractile failure in hypoxic rat hearts is not driven by ATP depletion or production limits, suggesting direct responsiveness of the inotropic state to ambient PO2 and increased non-contractile ATP hydrolysis.
Matthews et al. (1986) studied Acute contractile failure in the hypoxic rat heart. Hypoxic perfusion vs. Normoxic perfusion was evaluated on Mechanical activity and ATP utilization. Hypoxic perfusion in rat hearts caused a >80% reduction in mechanical activity without significantly decreasing the rate of ATP utilization, suggesting non-contractile processes hydrolyze ATP.
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