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April 1, 1973Circulation ResearchOpen Access

Biochemical Alterations Caused by Hypoxia in the Isolated Rabbit Aorta: CORRELATION WITH CHANGES IN ARTERIAL CONTRACTILITY

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Population

Isolated rabbit aorta strips

Comparison

Graded reduction in oxygen tension with varying… vs Normal oxygen tension / different glucose…

Design

Preclinical

Authors

DNDONALD H. NOMMBurroughs Wellcome FundJZJoan L. ZuckerBurroughs Wellcome Fund

Discussion

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Implication

May implicate creatine phosphate, not ATP, in hypoxic arterial tone; hypothesis-generating for metabolic modulation, pending human validation.

Structured PICO

P
Population
Isolated rabbit aorta strips
I
Intervention
Graded reduction in oxygen tension (hypoxia) with varying glucose concentrations (25 mM vs 5 mM) or pyruvate addition
C
Comparator
Normal oxygen tension / different glucose concentrations
O
Outcome
Changes in arterial contractility and biochemical alterations (creatine phosphate, ATP, glycogen, lactate)surrogate

Hypoxia-induced loss of arterial contractile tone correlates with decreased creatine phosphate rather than ATP depletion, suggesting subtle alterations in energy metabolism.

Cite This Study

NOMM et al. (1973) studied this question.

synapsesocial.com/papers/6a6fa217f44fa9f079dd1955https://doi.org/10.1161/01.res.32.4.464
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on the Effects of Drugs upon the Lactic Acid Metabolism and Contraction of Vascular Smooth Muscle1962 · 27 citations
  2. 2PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,678 citations
  3. 3Mechanism of the Relaxing Effect of: Adrenaline on Bovine Coronary Vessels1957 · 29 citations
  4. 4Absence of a Direct Effect of Phosphate or 5'-AMP on the Contractile Proteins of Hog Carotid Arteries1971 · 12 citations