Key result
In spontaneously beating rat atria, hypoxia-induced deterioration of contractility and termination of aerobic energy production were not mediated by cyclic nucleotides.
In a rat atrial model, hypoxia-induced deterioration of cardiac contractility and termination of aerobic energy production occur independently of cyclic nucleotide (cAMP and cGMP) signaling.
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Hypoxia effects on rat atria independent of cyclic nucleotides; hypothesis-generating for ischemic mechanisms, needs higher-model validation.
Metsä‐Ketelä et al. (1981) studied Hypoxia. Hypoxia vs. High oxygen saturation (HiOxSa) was evaluated on Cardiac contractility and glycolysis. In spontaneously beating rat atria, hypoxia-induced deterioration of contractility and termination of aerobic energy production were not mediated by cyclic nucleotides.
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