What is the clinical evidence from this study?

Study design: Observational. Population: Normal coronary arteries and haemodynamic function (n=10). Intervention: Biplane right ventriculograms with simultaneous micromanometer pressure measurements. Primary outcome: Right ventricular pressure-volume relation.

What does this research mean for the field?

Normal right ventricular pressure-volume loops are triangular and differ considerably from the square or rectangular loops of the normal left ventricle, with a mean ejection fraction of 62%. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize the normal right ventricular pressure-volume relation using biplane angiography and micromanometer pressure measurements.

January 1, 1988HeartOpen Access

Characterisation of the normal right ventricular pressure-volume relation by biplane angiography and simultaneous micromanometer pressure measurements.

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Key result

Normal right ventricular pressure-volume loops are triangular, differing considerably from the normal left ventricle, with a mean ejection fraction of 62%.

Population

10 adults found to have normal coronary arteries and haemodynamic function at diagnostic cardiac…

Design

Cross-sectional

Authors

ARAndrew N. RedingtonPediatric Cardiology HGHuon GrayInterventional Cardiology MHMark E. HodsonStockholm Environment Institute

Discussion

Member takes

Implication

Supports RV-specific hemodynamic evaluation in research; leaves open whether it alters clinical management in right heart disease.

Key Points

To characterize the normal right ventricular pressure-volume relation using biplane angiography and micromanometer pressure measurements.
Studied 10 adults with normal coronary arteries using biplane right ventriculograms and simultaneous pressure recordings.
Volume was measured frame by frame from digitized ventriculograms, with accuracy tested using human and animal casts.
Derived regression equations corrected in vivo calculated right ventricular volumes.
Mean end diastolic volume index was 62 (13) ml/m2; stroke volume index was 43 (8) ml/m2; ejection fraction was 62 (6)%.
Right ventricular pressure-volume loops were triangular, unlike the square shape of left ventricular loops.
Ejection began early during pressure rise and phases of isovolumic contraction and relaxation were difficult to define.

Study Design

Type

Observational (n=10)

Structured PICO

Population

10 adults found to have normal coronary arteries and haemodynamic function at diagnostic cardiac catheterisation, plus 22 human and animal right ventricular casts for method validation.

Intervention

Biplane right ventriculography with simultaneous high fidelity micromanometer pressure recordings.

Outcome

Right ventricular pressure-volume relation and loop characteristics.surrogate

The normal right ventricular pressure-volume loop is triangular and lacks distinct isovolumic contraction and relaxation phases, differing considerably from the left ventricle.

Cite This Study

Redington et al. (1988) conducted an observational in Normal coronary arteries and haemodynamic function (n=10). Biplane right ventriculograms with simultaneous micromanometer pressure measurements was evaluated on Right ventricular pressure-volume relation. Normal right ventricular pressure-volume loops are triangular, differing considerably from the normal left ventricle, with a mean ejection fraction of 62%.

synapsesocial.com/papers/6a1577f7d64fa333899fb467 https://doi.org/10.1136/hrt.59.1.23

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Characterisation of the normal right ventricular pressure-volume relation by biplane angiography and simultaneous micromanometer pressure measurements.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Characterisation of the normal right ventricular pressure-volume relation by biplane angiography and simultaneous micromanometer pressure measurements.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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Also Consider