Key result
Intravenous verapamil significantly improved the time constant of left ventricular pressure decay in hypertrophic cardiomyopathy (79 to 60 msec, p<.001) but delayed it in aortic stenosis.
Why the study?
Does intravenous verapamil improve left ventricular relaxation in patients with myocardial hypertrophy (hypertrophic cardiomyopathy and aortic stenosis)?
Does intravenous verapamil improve left ventricular relaxation in patients with myocardial hypertrophy (hypertrophic cardiomyopathy and aortic stenosis)?
Absolute Event Rate: 60% vs 79%
p-value: p=<.001
Intravenous verapamil improves left ventricular relaxation in patients with hypertrophic cardiomyopathy but delays it in patients with aortic stenosis.
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Verapamil was associated with improved left ventricular relaxation in hypertrophic cardiomyopathy but delayed it in aortic stenosis; hypothesis-generating for differential effects in hypertrophy.
Hess et al. (1986) studied Hypertrophic cardiomyopathy and aortic stenosis (n=23). Verapamil vs. Baseline (rest) was evaluated on Time constant of left ventricular pressure decay (T) in hypertrophic cardiomyopathy (msec) (p=<.001). Intravenous verapamil significantly improved the time constant of left ventricular pressure decay in hypertrophic cardiomyopathy (79 to 60 msec, p<.001) but delayed it in aortic stenosis.
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