Key result
Acute intravenous verapamil increased the time constant of relaxation (+15%, p<0.001), whereas 18-week oral verapamil decreased heart rate (-16%, p<0.0005) in patients with HCM.
Why the study?
Do acute intravenous and chronic oral verapamil have different effects on left ventricular diastolic function in patients with hypertrophic cardiomyopathy?
Do acute intravenous and chronic oral verapamil have different effects on left ventricular diastolic function in patients with hypertrophic cardiomyopathy?
p-value: p=<0.001
Acute intravenous and chronic oral verapamil exert differing hemodynamic effects on diastolic function in patients with hypertrophic cardiomyopathy.
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Acute IV verapamil effects in HCM warrant cautious interpretation; Level 5 data leaves open differential impact versus long-term oral therapy.
Posma et al. (1994) studied Hypertrophic cardiomyopathy (n=20). Verapamil (acute intravenous vs chronic oral) vs. Baseline was evaluated on Diastolic function (time constant of relaxation) (p=<0.001). Acute intravenous verapamil increased the time constant of relaxation (+15%, p<0.001), whereas 18-week oral verapamil decreased heart rate (-16%, p<0.0005) in patients with HCM.
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