Key result
Adequate cardiorespiratory fitness is linked to up to ~91% prevention of adverse ventricular parameters and LGE.
Why the study?
Anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukemia survivors might be prevented with good cardiorespiratory fitness and physical activity, but their associations with CMR parameters needed assessment.
Does adequate cardiorespiratory fitness and regular physical activity improve cardiac magnetic resonance parameters in childhood acute lymphoblastic leukemia survivors?
Cross-Sectional (n=96)
Does adequate cardiorespiratory fitness and regular physical activity improve cardiac magnetic resonance parameters in childhood acute lymphoblastic leukemia survivors?
Adequate cardiorespiratory fitness, but not self-reported regular physical activity, is associated with better cardiac magnetic resonance parameters in childhood acute lymphoblastic leukemia survivors.
Supports fitness assessment in ALL survivors; leaves open whether exercise improves ventricular parameters.
BACKGROUND: Childhood acute lymphoblastic leukemia survivors' anthracycline-induced cardiotoxicity could be prevented with good cardiorespiratory fitness levels and regular physical activity. This cross-sectional study aimed to assess the association between cardiorespiratory fitness and physical activity with cardiac magnetic resonance parameters. METHODS: A total of 96 childhood acute lymphoblastic leukemia survivors underwent a maximal cardiopulmonary exercise test and answered physical activity questionnaires. We calculated the odds ratio of the preventive fraction of regular physical activity (≥150 min/wk) and adequate cardiorespiratory fitness levels (above the median ≥31.4 mL·kg-1·min-1) on cardiac magnetic resonance parameters (left ventricular [LV] and right ventricular [RV] morphological and functional parameters). RESULTS: An adequate cardiorespiratory fitness was associated with a significant preventive fraction for LV (up to 84% for LV end-diastolic volume) and RV volumes (up to 88% for RV end-systolic volume). The adjusted analyses highlighted a preventive fraction of 36% to 91% between an adequate cardiorespiratory fitness and LV and RV parameters, late gadolinium enhancement fibrosis, and cardiac magnetic resonance relaxation times. No associations were reported with regular physical activity. CONCLUSIONS: This study provides additional evidence regarding the benefits of an adequate cardiorespiratory fitness level for childhood cancer survivors' cardiac health.
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Caru et al. (2023) conducted a cross-sectional in Childhood acute lymphoblastic leukemia survivors (n=96). Adequate cardiorespiratory fitness (≥31.4 mL·kg-1·min-1) and regular physical activity vs. Lower cardiorespiratory fitness was evaluated on Cardiac magnetic resonance parameters (left and right ventricular morphological and functional parameters) (Preventive fraction 36% to 91%). Adequate cardiorespiratory fitness (≥31.4 mL·kg-1·min-1) was associated with a significant preventive fraction of 36% to 91% for left and right ventricular parameters and late gadolinium enhancement.
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