What does this research mean for the field?

A unique set of high molecular weight proteins localized specifically to the junctional sarcoplasmic reticulum of cardiac and skeletal muscle bind calmodulin, undergo phosphorylation, and are degraded by Ca2+-activated protease, suggesting they are homologous and share similar functions across striated muscle types. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1984Journal of Biological ChemistryOpen Access

High molecular weight proteins in cardiac and skeletal muscle junctional sarcoplasmic reticulum vesicles bind calmodulin, are phosphorylated, and are degraded by Ca2+-activated protease.

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Population

Junctional sarcoplasmic reticulum (SR) vesicles isolated from cardiac muscle and skeletal muscle

Comparison

Biochemical characterization vs Free SR vesicles and purified sarcolemmal…

Design

Preclinical

Authors

SSSteven M. SeilerLock Haven University AWA D WegenerRichard L. Roudebush VA Medical Center DWDavid D. WhangCenter for Brooklyn History

Discussion

Member takes

Implication

May represent novel SR regulators in striated muscle; hypothesis-generating and leaves open their roles pending identification and functional studies.

Structured PICO

Population

Junctional sarcoplasmic reticulum (SR) vesicles isolated from cardiac muscle and skeletal muscle

Intervention

Biochemical characterization (calmodulin binding, phosphorylation, and protease degradation assays)

Comparator

Free SR vesicles and purified sarcolemmal fractions

Outcome

Identification and biochemical properties of high molecular weight proteinssurrogate

Identifies a unique set of high molecular weight proteins in junctional SR of striated muscle with nearly identical biochemical properties, suggesting homologous functions.

Cite This Study

Seiler et al. (1984) studied this question.

synapsesocial.com/papers/6a157b1272316eef384e267e https://doi.org/10.1016/s0021-9258(17)39765-x

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Implication

May represent novel SR regulators in striated muscle; hypothesis-generating and leaves open their roles pending identification and functional studies.

High molecular weight proteins in cardiac and skeletal muscle junctional sarcoplasmic reticulum vesicles bind calmodulin, are phosphorylated, and are degraded by Ca2+-activated protease.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High molecular weight proteins in cardiac and skeletal muscle junctional sarcoplasmic reticulum vesicles bind calmodulin, are phosphorylated, and are degraded by Ca2+-activated protease.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider