Key result
SBP ≥170 mmHg linked to ~53% higher all-cause mortality vs 130-150 mmHg in frail older adults.
Why the study?
The optimal blood pressure for elderly individuals with frailty or prefrailty remains unclear.
Does blood pressure level affect all-cause and cardiac mortality in elderly patients with frailty or prefrailty?
Population
528 participants aged 60 years and older with (pre)frailty from NHANES (1999–2004)
Comparison
Blood pressure levels compared across categories including SBP < 110 and ≥ 170 mmHg vs 130–150 mmHg
Design
Observational cohort study
Follow-up
Median 116.5 months
Authors
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High SBP ≥170 mmHg was associated with higher mortality in frail elderly; leaves open optimal targets pending randomized trials.
Observational (n=528)
Does blood pressure level affect all-cause and cardiac mortality in elderly patients with frailty or prefrailty?
Effect estimate: HR 1.53 (95% CI 1.09-2.15)
p-value: p=0.015
In older adults with frailty or prefrailty, there is a J-shaped association between systolic blood pressure and mortality, suggesting an optimal SBP target of approximately 140 mmHg.
Li et al. (2022) conducted an observational in Frailty or prefrailty (n=528). Systolic blood pressure ≥170 mmHg vs. Systolic blood pressure 130-150 mmHg was evaluated on All-cause mortality (HR 1.53, 95% CI 1.09-2.15, p=0.015). Systolic blood pressure ≥170 mmHg was associated with a 53% increased risk of all-cause mortality compared to 130-150 mmHg in older individuals with frailty or prefrailty.
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