Key result
In patients aged 75-84 with moderate/severe frailty, systolic blood pressure of 150-159 mmHg was associated with lower mortality compared to 130-139 mmHg (HR 0.84; 95% CI 0.77-0.92).
Why the study?
All-cause mortality by attained BP in routine care in frail adults aged above 75 remains unclear, making BP management challenging.
Does baseline blood pressure level affect cardiovascular events and mortality in primary-care patients aged above 75?
Population
415,980 primary-care patients aged above 75 stratified by frailty
Comparison
Baseline BP levels vs reference SBP of 130-139 mmHg
Design
Prospective observational analysis of electronic health records
Follow-up
<=10 years
Authors
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Supports relaxed SBP targets in frail elderly; hypothesis-generating and requires RCT confirmation before practice change.
Observational (n=415,980)
Does baseline blood pressure level affect cardiovascular events and mortality in primary-care patients aged above 75?
Hazard Ratio: 0.84 (95% CI 0.77–0.92)
In frail older adults aged ≥75, blood pressure <130/80 mmHg is associated with excess mortality, suggesting that aggressive blood pressure reduction may not be beneficial in this population.
Masoli et al. (2020) conducted an observational in Frail older adults (n=415,980). Systolic blood pressure 150-159 mmHg vs. Systolic blood pressure 130-139 mmHg was evaluated on Mortality (HR 0.84, 95% CI 0.77-0.92). In patients aged 75-84 with moderate/severe frailty, systolic blood pressure of 150-159 mmHg was associated with lower mortality compared to 130-139 mmHg (HR 0.84; 95% CI 0.77-0.92).
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