Key result
Diabetes, smoking, and antihypertensive use are linked to higher 10-year CVD risk in older adults.
Why the study?
Cardiovascular risk estimation in people over 70 years is problematic, as most scores were derived from middle-aged cohorts and the predictive power of classical risk factors reduces with age.
Cohort (n=3,474)
Yes
The EPICARDIAN risk score provides a specific 10-year cardiovascular risk estimation for adults over 64 in Spain, highlighting that age, diabetes, smoking, and antihypertensive treatment are strong predictors, whereas total cholesterol is not.
May inform local risk stratification in elderly Spaniards; leaves open prospective validation before clinical adoption.
Background : Cardiovascular risk estimation in people over 70 years is problematic. Most scores have been derived from cohorts of middle-aged people, with older persons under-represented. The predictive power of classical cardiovascular risk factors reduce with age. The aim is to develop a specific score for the elderly population Methods : Population-based cohort established in 1995. Setting: Three geographical areas of Spain (Madrid, Ávila and Lugo). Participants: 3,729 people older than 64 years, free of any cardiovascular diseases (CVD), at baseline. Measurements: Suspected fatal and nonfatal CVD (both coronary heart disease and stroke) were yearly investigated and confirmed using the WHO-MONICA criteria. All participants were followed until the occurrence of the first CVD event, until death or until December 31th 2015 if alive. Results : Age was the strongest predictor of 10-year CVD both in men and women. In men, variables associated to CVD were high blood pressure treatment (HR: 1,35; 95% CI: 1,067 , 1,710), diabetes (HR: 1,359; 95% CI: 0,997 , 1,852) and smoking (HR:1,207; 95%CI: 0,945 , 1,541), and in women smoking (HR: 1,881 95%CI: 1,356 , 2,609) and diabetes (HR:1,285; 95%CI:0,967 , 1,707). Total-cholesterol did not increased the risk of CVD either in males or females. However, total-cholesterol level (>200mg/dl) were negatively associated both in men and women. Conclusions : In old Spanish men, 10-year total CVD is significantly increased by age, diabetes and antihypertensive treatment, and in old women by diabetes and smoking. Total-cholesterol levels did not increased the risk of CVD either in males or females.
No takes yet. Share an insight, caveat, or question.
Gabriel et al. (2020) conducted a cohort in Cardiovascular risk in the elderly (n=3,474). Cardiovascular risk factors was evaluated on 10-year total (fatal and non-fatal) cardiovascular disease. In Spanish adults over 64 years old, 10-year cardiovascular disease risk was significantly increased by diabetes and antihypertensive treatment in men, and by smoking and diabetes in women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: