Key result
A multimodal approach using acetylsalicylic acid reduced the overall complication rate compared to enoxaparin in patients undergoing primary total hip arthroplasty.
Why the study?
Does a multimodal approach with acetylsalicylic acid reduce complications and effectively prevent thromboembolism compared to enoxaparin in patients undergoing primary total hip arthroplasty?
Cohort (n=242)
Yes
Does a multimodal approach with acetylsalicylic acid reduce complications and effectively prevent thromboembolism compared to enoxaparin in patients undergoing primary total hip arthroplasty?
In patients without predisposing factors undergoing primary total hip arthroplasty, a multimodal approach using aspirin is effective for thromboembolism prophylaxis and significantly reduces hemorrhagic complications and costs compared to enoxaparin.
Answers are grounded in this paper and cite their sources.
May support aspirin multimodal prophylaxis in primary THA; leaves open confirmation by randomized trials before practice change.
Objective: To demonstrate the efficacy and safety of a multimodal stratified approach for prevention of thromboembolism in patients undergoing primary total hip arthroplasty. Method: A longitudinal retrospective clinical study of a cohort of 341 individuals undergoing total hip arthroplasty between March 2008 and July 2016. Of these, 242 patients met the criteria for inclusion in the study. Individuals with a history of deep vein thrombosis or pulmonary thromboembolism, thrombophilia, hypercoagulation conditions, and chronic users of anticoagulants before surgery received enoxaparin at a dose of 40 mg/day for 21 days. For the other group, acetylsalicylic acid was prescribed at a dose of 200 mg/day for 30 days. All patients had surgical risk assessed by the American Anesthesiology Association classified as I or II, and underwent regional anesthesia, effective hydration, the same protocol of early postoperative rehabilitation, and the use of compression stockings. Drug cost analysis was performed based on the Brasíndice. To date, there are no publications in PubMed and Scielo on this subject regarding the Brazilian population. Results: The need for blood transfusion in the enoxaparin group was higher and the overall complication and hemorrhagic rates were also significantly higher (p < 0.010) in this group. Aspirin prescription costs 39 times less than enoxaparin. Conclusion: In patients without predisposing factors to thromboembolism and undergoing primary total hip arthroplasty, the multimodal approach with acetylsalicylic acid seems to be effective, with low cost and a low rate of complications.
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Loures et al. (2018) conducted a cohort in Primary total hip arthroplasty (n=242). Acetylsalicylic acid vs. Enoxaparin 40 mg/day was evaluated on Overall complications (p=<0.001). A multimodal approach using acetylsalicylic acid reduced the overall complication rate compared to enoxaparin in patients undergoing primary total hip arthroplasty.
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