Key result
Aspirin and enoxaparin were associated with a lower risk of any postoperative bleeding compared to rivaroxaban (P < .05) following elective total hip or knee arthroplasty.
Why the study?
Does the choice of thromboprophylaxis (rivaroxaban, enoxaparin, or aspirin) affect postoperative bleeding rates in patients undergoing elective total hip or knee arthroplasty?
Population
1244 patients undergoing elective total hip arthroplasty or total knee arthroplasty
Comparison
Thromboprophylaxis with rivaroxaban, enoxaparin… vs Compared against each other
Design
Cohort
Authors
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Rivaroxaban may confer higher bleeding risk than aspirin or enoxaparin after arthroplasty; leaves open need for randomized confirmation before changing prophylaxis.
Cohort (n=1,244)
Does the choice of thromboprophylaxis (rivaroxaban, enoxaparin, or aspirin) affect postoperative bleeding rates in patients undergoing elective total hip or knee arthroplasty?
p-value: p=<.05
Aspirin and enoxaparin may offer a safer bleeding profile compared to rivaroxaban for thromboprophylaxis following elective hip or knee arthroplasty.
Lindquist et al. (2018) conducted a cohort in Elective total hip arthroplasty or total knee arthroplasty (n=1,244). Aspirin or Enoxaparin vs. Rivaroxaban was evaluated on Any postoperative bleeding (p=<.05). Aspirin and enoxaparin were associated with a lower risk of any postoperative bleeding compared to rivaroxaban (P < .05) following elective total hip or knee arthroplasty.
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