Why the study?
Does oral milrinone improve hemodynamics and survival in dogs with severe idiopathic myocardial failure?
Population
13 dogs with severe idiopathic myocardial failure (dilated cardiomyopathy)
Comparison
Oral milrinone 0.75 mg/kg and prolonged… vs Baseline (before drug administration)
Design
Preclinical
Follow-up
2 hours (hemodynamics), up to >2 years (survival)
Authors
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Acute hemodynamic gains in canine DCM model; leaves open survival effects and arrhythmia safety for translation.
Does oral milrinone improve hemodynamics and survival in dogs with severe idiopathic myocardial failure?
Oral milrinone acutely improves hemodynamics in dogs with severe dilated cardiomyopathy but may be associated with fatal tachyarrhythmias.
Kittleson et al. (1987) studied this question.
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