Key result
Pediatric heart failure management requires childhood-specific registries and pediatric-specific descriptors rather than extrapolating adult clinical trials.
This review emphasizes the necessity of developing pediatric-specific guidelines, registries, and research models for managing chronic heart failure in children, rather than relying on extrapolated adult data.
Warrants caution extrapolating adult HF trials to children; supports dedicated pediatric registries and descriptors.
Objectives: The objectives of this review are to discuss the paradigms used to stage heart failure in children, the classification and physiologic profile of cardiomyopathies, and the acute and chronic pharmacologic management of heart failure. Data Source: MEDLINE, PubMed. Conclusion: The etiology of chronic heart failure in pediatrics is vast. The paradigm of extrapolating adult clinical trials and technological advancements to treat heart failure in children has become a nonsustainable model. The field of pediatric heart failure continues to advance with more robust guideline-directed care and the imminent creation of a dynamic, contemporary international database. As the field involves a markedly heterogeneous patient population, it is imperative to use pediatric specific descriptors of disease impact. The fields of pediatric heart failure and critical care medicine will continue to evolve together as childhood specific registries, quality improvement guidelines, and research will lead to practice models eliciting optimal therapy for patients with heart failure in the intensive care setting.
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Timothy M. Hoffman (2016) conducted a review in Chronic Heart Failure. Pediatric heart failure management requires childhood-specific registries and pediatric-specific descriptors rather than extrapolating adult clinical trials.
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