Why the study?
Does myocardial hypertrophy alter myocardial distensibility in a rat model of aortic constriction?
Does myocardial hypertrophy alter myocardial distensibility in a rat model of aortic constriction?
Myocardial hypertrophy does not inherently alter myocardial distensibility when corrected for muscle mass and cross-sectional area in a rat model.
Hypertrophy does not alter distensibility after mass correction in rats; leaves open relevance to human diastolic function.
SummaryLength-resting tension curves were recorded from strips of left ventricle obtained from 10 rats with myocardial hypertrophy produced by subdiaphragmatic suprarenal aortic constriction, and 8 rats subjected to aortic constriction in which hypertrophy did not develop. No differences were noted between the distensibility of the normal and hypertrophied myocardium after corrections were made for differences in muscle mass and cross-sectional area.
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Williams et al. (1966) studied this question.
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