Key result
Ambulatory arterial stiffness index independently predicted cardiovascular mortality and was a stronger predictor of stroke mortality than pulse pressure (HR 1.21 vs 1.04 per 1 SD increase; P=0.02).
Why the study?
Does the ambulatory arterial stiffness index (AASI) predict cardiovascular mortality in patients undergoing ambulatory blood pressure monitoring?
Population
11,291 patients undergoing ambulatory blood pressure monitoring at baseline while not on antihypertensive…
Comparison
Ambulatory arterial stiffness index derived from… vs Pulse pressure
Design
Cohort
Follow-up
median 5.3 years
Authors
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May enhance risk stratification during ambulatory monitoring; extends pulse pressure data but leaves open prospective validation.
Cohort (n=11,291)
Does the ambulatory arterial stiffness index (AASI) predict cardiovascular mortality in patients undergoing ambulatory blood pressure monitoring?
Effect estimate: HR 1.21
p-value: p=0.02
AASI, derived from ambulatory blood pressure monitoring, independently predicts cardiovascular and stroke mortality, offering prognostic value beyond pulse pressure even in normotensive subjects.
Dolan et al. (2006) conducted a cohort in Cardiovascular risk assessment (n=11,291). Ambulatory Arterial Stiffness Index (AASI) vs. Pulse pressure was evaluated on Stroke mortality (per 1 SD increase) (HR 1.21, p=0.02). Ambulatory arterial stiffness index independently predicted cardiovascular mortality and was a stronger predictor of stroke mortality than pulse pressure (HR 1.21 vs 1.04 per 1 SD increase; P=0.02).
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