Key result
Additive genetic factors moderately influence the occurrence of a first acute myocardial infarction episode in both sexes, with an estimated heritability of 0.36.
Observational (n=41,492)
Liability to the first occurrence of acute myocardial infarction is moderately influenced by additive genetic factors in both sexes, with an estimated heritability of 36%.
Answers are grounded in this paper and cite their sources.
Supports moderate genetic role in first MI risk; leaves open validation for clinical risk tools or screening.
The aim of this study was to determine the influence of genetic factors on the first episode of acute myocardial infarction. Probandwise concordances, tetrachoric correlations and quantitative genetic analyses of liability were applied to data drawn from the Swedish Twin Registry and the Swedish Acute Myocardial Infarction Register. All same-sexed twin pairs born between 1886 and 1958 who were alive in 1987 were included in the analyses. Our results show that concordance rates for acute myocardial infarction in monozygotic (MZ) twins were similar across sexes (among males .26 and females .27). For dizygotic (DZ) twins the concordances were .20 for males and .16 for females, yielding a greater MZ-DZ concordance differential for females than males. Tetrachoric correlations were greater for MZ than DZ twins for both sexes (.49 for male MZ and .34 for male DZ-twins and .56 and .35 for female MZ and DZ twins respectively). Quantitative genetic analyses of liability resulted in equal variance components for males and females (.36) but significantly different thresholds (prevalences). In conclusion, liability to first occurrence of acute myocardial infarction is moderately influenced by genetic variants in both sexes. The familial influence on phenotypic variance is exclusively explained by additive genetic factors.
No takes yet. Share an insight, caveat, or question.
Zdravkovic et al. (2007) conducted an observational in Acute myocardial infarction (n=41,492). Monozygotic twins vs. Dizygotic twins was evaluated on Heritability of first episode of acute myocardial infarction (Heritability 0.36). Additive genetic factors moderately influence the occurrence of a first acute myocardial infarction episode in both sexes, with an estimated heritability of 0.36.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: