Key result
Early menopause linked to ~36% higher risk of first MI in Chinese women.
Why the study?
Little was known about whether early menopause in Chinese ethnicity is associated with acute myocardial infarction.
Does early menopause increase the risk of first acute myocardial infarction in Chinese women?
Case-Control (n=1,771)
Yes
Does early menopause increase the risk of first acute myocardial infarction in Chinese women?
Effect estimate: OR 1.36 (95% CI 1.03-1.79)
Early menopause (<50 years) is independently associated with an increased risk of first acute myocardial infarction in Chinese women.
May inform AMI risk stratification in Chinese women; extends case-control data but leaves causal inference open.
Background and Aim: Little is known about whether early menopause in Chinese ethnicity is associated with acute myocardial infarction (AMI). We aimed to determine whether self-reported early menopause (either surgical or natural menopause at an age <50 year) was associated with first AMI in Chinese women. Methods: The study population was from the INTERHEART China Study, part of the INTERHEART global study. INTERHEART global study was a standardized case–control study that was designed to evaluate the risk factors for first AMI among 52 countries. Data for demographic factors, education, income, and cardiovascular risk factors were obtained by structured questionnaires. A standard set of questions that inquired about menstrual history was included in the interview. Results: Of the 1,771 Chinese women, 1,563 (88.3%) reported either natural or surgical menopause. In univariate logistic regression model, women with early menopause had higher risk of AMI (odds ratio [OR]: 1.51; 95% confidence interval [CI]: 1.23–1.87). After controlling for age, birth control measures, type of menopause, and other traditional risk factors (including waist/hip ratio, lifestyle factors, history of hypertension and diabetes, psychosocial factors, and apolipoprotein B [ApoB]/A1 [ApoA1]), the risk for AMI remained (OR: 1.36; 95% CI: 1.03–1.79). The population attributable risk for AMI in women with early menopause at <50 years was 10.1% (95% CI: 4.0–20.0) compared with women who had menopause at ≥50 years. Conclusion: Early menopause is associated with increased risk of AMI in Chinese women, independent of other traditional coronary heart disease risk factors.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2023) conducted a case-control in Acute myocardial infarction (n=1,771). Early menopause (<50 years) vs. Menopause at ≥50 years was evaluated on First acute myocardial infarction (OR 1.36, 95% CI 1.03-1.79). Early menopause (<50 years) was associated with an increased risk of first acute myocardial infarction in Chinese women compared to menopause at ≥50 years (adjusted OR 1.36; 95% CI 1.03-1.79).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: