Why the study?
Patients with cardiovascular disease are increasingly older with more comorbidities, but limited data are available regarding the prognostic impact of age in cardiogenic shock.
Does age > 80 years increase 30-day all-cause mortality in patients with cardiogenic shock compared to age 60-80 years?
Population
223 consecutive patients with cardiogenic shock of any cause
Comparison
Age > 80 years vs 60–80 years, stratified by AMI-related etiology
Design
Cohort study
Follow-up
30 days
Key result
Age >80 years was not associated with 30-day all-cause mortality in mixed-etiology cardiogenic shock (HR 1.273; 95% CI 0.886-1.831; P=0.192), but increased mortality risk in AMI-related shock.
Authors
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Does not support age >80 as uniform mortality predictor in mixed cardiogenic shock; leaves open etiology-specific risk modeling for prospective validation.
Cohort (n=223)
Does age > 80 years increase 30-day all-cause mortality in patients with cardiogenic shock compared to age 60-80 years?
Effect estimate: HR 1.273 (95% CI 0.886-1.831)
Absolute Event Rate: 63.4% vs 54.6%
p-value: p=0.192
Age >80 years is a significant predictor of increased 30-day mortality specifically in patients with AMI-related cardiogenic shock, but not in mixed-etiology cardiogenic shock.
Schmitt et al. (2023) conducted a cohort in Cardiogenic shock (n=223). Age > 80 years vs. Age 60-80 years was evaluated on 30-day all-cause mortality (HR 1.273, 95% CI 0.886-1.831, p=0.192). Age >80 years was not associated with 30-day all-cause mortality in mixed-etiology cardiogenic shock (HR 1.273; 95% CI 0.886-1.831; P=0.192), but increased mortality risk in AMI-related shock.