Key result
Ambulatory and conventional isolated systolic hypertension linked to higher PWV and LVMI versus normotensives.
Why the study?
Diagnosis of ISH relies mainly on conventional blood pressure techniques, ABPM studies have been limited to 24-hour BP, and the prevalence of ambulatory ISH subtypes was unknown.
Are ambulatory and conventional subtypes of isolated systolic hypertension associated with increased cardiovascular target organ damage compared to normotension in people of African ancestry?
Cross-Sectional (n=549)
Are ambulatory and conventional subtypes of isolated systolic hypertension associated with increased cardiovascular target organ damage compared to normotension in people of African ancestry?
Ambulatory subtypes of isolated systolic hypertension are associated with significant cardiovascular target organ damage, comparable to general hypertension, highlighting the importance of ambulatory blood pressure monitoring.
Supports ISH subtype associations with target organ damage in African ancestry; leaves open prospective validation before guiding ABPM use.
Isolated systolic hypertension (ISH) is a major contributor to cardiovascular disease morbidity and mortality worldwide, however, diagnosis of ISH is mainly dependent on conventional blood pressure (BP) techniques. Studies that have used ambulatory blood pressure monitoring (ABPM) were only limited to 24-hour BP. To date ambulatory isolated BP subtypes have never been identified. Therefore, the prevalence of ambulatory subtypes of ISH unknown. Conventional and ambulatory BP was measure in 549 participants and based on the results, they were stratified into ISH subtypes (Conventional, Daytime, Night-time and 24-hour ISH). Participants further underwent measurements of pulse wave velocity (PWV) and left ventricular mass index (LVMI) to determine the extent of arterial stiffness and left ventricular hypertrophy. We further assessed whether the target organ changes are associated with any ISH subtype. The prevalence of Conventional ISH (ISHC), 24-hour ISH (ISH24), Night-time ISH (ISHN) and Daytime ISH (ISHD) was 7.5%, 7.1%, 7.7% and 7.5% respectively. Compared to normotensives, all ISH subtypes had higher PWV and LVMI. These target organ changes were similar to those observed in hypertensives. Our results indicate that isolated systolic hypertension, whether conventional or ambulatory, is as detrimental as hypertension on cardiovascular target organs.
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Maseko et al. (2021) conducted a cross-sectional in Isolated systolic hypertension (n=549). Ambulatory blood pressure monitoring (ABPM) vs. Normotensives and hypertensives was evaluated on Prevalence of ISH subtypes and cardiovascular target organ damage (PWV and LVMI). Ambulatory and conventional subtypes of isolated systolic hypertension (prevalence 7.1-7.7%) were associated with higher pulse wave velocity and left ventricular mass index compared to normotensives.
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