Key result
Prediabetes shows no difference in FMD compared to healthy controls.
Why the study?
Prediabetes enables identification of risk factors to prevent diabetic complications, and endothelial dysfunction is an early manifestation of atherosclerosis in hyperglycemic states that can be evaluated using brachial artery flow-mediated dilatation.
Does prediabetes impair endothelial function as measured by Flow Mediated Dilatation compared to healthy controls?
Case-Control (n=100)
No
Does prediabetes impair endothelial function as measured by Flow Mediated Dilatation compared to healthy controls?
Absolute Event Rate: 14.27% vs 15.5%
p-value: p=0.369
In a rural setting, prediabetes alone did not significantly reduce FMD, but endothelial dysfunction in this population was significantly associated with obesity and lipid parameters.
Prediabetes did not impair FMD; leaves open obesity and lipids as drivers of dysfunction in this population.
Background: Diabetes mellitus is a life-threatening disease that affects both developing and industrialised countries. Prediabetes is a state where identification of the risk factors can help in preventing the complications of diabetes. Coronary artery disease and cardiovascular disease result from atherosclerosis seen in hyperglycemic states which is manifested early on as endothelial dysfunction. In this study, we used flow mediated dilatation (FMD) of brachial artery with ultrasound which gives knowledge about endothelial function in disease as well as health. Aims: To assess endothelial function in individuals diagnosed with prediabetes using FMD of brachial artery and compare it with healthy non-diabetic subjects. We also assessed if FMD was affected by anthropometric parameters or lipid profile. Methods: This case control research comprised of 50 patients who met the American Diabetes Association prediabetes criteria (ADA) and 50 controls. Clinical history was taken and data related to brachial artery diameter at baseline and post hyperemia was taken and FMD% was calculated. Results: Out of 50 patients, 4 patients had FMD (<4.5%) and were classified as having endothelial dysfunction. It was found that patients classified as Obese as per BMI (kg/m 2 ) were significantly higher in cases that had FMD<4.5% (27.08 0.97 vs. 23.51 2.54, p value=0.008). Conclusion: Individuals with prediabetes did not have significantly lower brachial artery diameter at baseline, post-hyperemia brachial artery diameter and FMD. But we found that diameters of the brachial artery at rest and post stress and FMD% were significantly affected by parameters like LDL, waist circumference and BMI.
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Gupte et al. (2022) conducted a case-control in Prediabetes (n=100). Prediabetes vs. Healthy non-diabetic controls was evaluated on Flow Mediated Dilatation (FMD %) (p=0.369). Individuals with prediabetes did not have significantly lower Flow Mediated Dilatation compared to healthy controls (14.27% vs 15.5%, p=0.369).
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