Key result
Metabolic syndrome was associated with significantly lower brachial artery flow-mediated dilation compared to age- and sex-matched controls (7.24% vs 21.29%; P=0.000).
Why the study?
Assessment of brachial artery flow-mediated dilation has been proposed as a non-invasive marker for cardiovascular risk, but its relationship with metabolic syndrome and its risk factors warranted evaluation.
Is metabolic syndrome associated with impaired endothelial function as measured by flow-mediated vasodilatation?
Case-Control (n=100)
Is metabolic syndrome associated with impaired endothelial function as measured by flow-mediated vasodilatation?
Absolute Event Rate: 7.24% vs 21.29%
p-value: p=0.000
Metabolic syndrome is significantly associated with endothelial dysfunction as evidenced by reduced flow-mediated vasodilatation, which correlates negatively with the number of metabolic risk factors.
Supports endothelial dysfunction link in metabolic syndrome; hypothesis-generating and should not yet change practice.
Background: Metabolic syndrome (MetS) is characterized by clustering of cardiovascular risk factors.Endothelial dysfunction is the key early event in atherogenesis that occurs long before structural atherosclerotic changes and promotes cardiovascular events. The assessment of endothelial function by flow-mediated dilation (FMD) of the brachial artery has been proposed as a non-invasive marker for cardiovascular risk. Aim: Assessment of flow mediated vasodilatation of brachial artery as a non invasive marker of endothelial function in metabolic syndrome and To assess the relationship of number of risk factors in metabolic syndrome with endothelial dysfunction. Methodology: A case control study in which 50 patients with Metabolic Syndrome as per new IDF criteria and 50 controls were studied. Detailed clinical history, examination and Blood investigations like Fasting blood glucose, fasting lipid profile and ECG was done for every patients. Endothelial function was assessed by brachial artery flow mediated vasodilatation. Results: In the present study 100 (50 cases and 50 controls) patients were studied, males (54%) and females (46%), majority in the age group between 40-60 years (mean age - 49.76 ± 13.76yrs in cases and 44.94 ± 16.09 years among controls). We identified a significant difference between cases and age- and sex-matched controls regarding brachial artery FMD% (7.24 ± 5.24 and 21.29 ± 9.29 respectively; P value-0.000). Negative corelations were found between FMD% and various variables and also between number of components and FMD% (r = -0.239). Conclusion: MetS is associated with endothelial dysfunction as evidenced by decreased FMD% compared to controls. There is a negative correlation between various components of MetS, number of components of MetS and FMD%.
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Narsimhamurthy et al. (2020) conducted a case-control in Metabolic syndrome (n=100). Metabolic syndrome vs. Age- and sex-matched controls was evaluated on Brachial artery flow-mediated vasodilatation (FMD%) (p=0.000). Metabolic syndrome was associated with significantly lower brachial artery flow-mediated dilation compared to age- and sex-matched controls (7.24% vs 21.29%; P=0.000).
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