Why the study?
Does insulin resistance syndrome predict the risk of coronary heart disease and stroke in healthy middle-aged men?
Population
970 healthy men aged 34 to 64 years from the Helsinki Policemen Study
Design
Cohort
Follow-up
22 years
Key result
An insulin resistance factor significantly predicted the risk of coronary heart disease (HR 1.28; 95% CI 1.10-1.50) and stroke (HR 1.64; 95% CI 1.29-2.08) over a 22-year follow-up in healthy men.
Authors
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May inform risk stratification in healthy men; extends factor analyses but leaves open causal confirmation in trials.
Cohort (n=970)
Does insulin resistance syndrome predict the risk of coronary heart disease and stroke in healthy middle-aged men?
Effect estimate: HR 1.28 for CHD; HR 1.64 for stroke (95% CI 1.10-1.50 for CHD; 1.29-2.08 for stroke)
Insulin resistance syndrome, identified through factor analysis, independently predicts the long-term risk of coronary heart disease and stroke in healthy middle-aged men.
Pyörälä et al. (2000) conducted a cohort in Healthy men (n=970). Insulin resistance factor was evaluated on Coronary heart disease (CHD) and stroke (HR 1.28 for CHD; HR 1.64 for stroke, 95% CI 1.10-1.50 for CHD; 1.29-2.08 for stroke). An insulin resistance factor significantly predicted the risk of coronary heart disease (HR 1.28; 95% CI 1.10-1.50) and stroke (HR 1.64; 95% CI 1.29-2.08) over a 22-year follow-up in healthy men.