July 19, 2005JAMA
Insulin Resistance and Risk of Congestive Heart Failure
Why the study?
Does insulin resistance predict the incidence of congestive heart failure in elderly men?
Population
1187 elderly men free from congestive heart failure and valvular disease at baseline from the Uppsala…
Design
Cohort
Follow-up
median 8.9 years
Authors
Discussion
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Member takes
Implication
Insulin resistance may independently predict CHF in elderly men beyond obesity; hypothesis-generating and should not yet change practice.
Structured PICO
Does insulin resistance predict the incidence of congestive heart failure in elderly men?
P
Population
1187 elderly (≥70 years) men free from congestive heart failure and valvular disease at baseline from the Uppsala Longitudinal Study of Adult Men
I
Intervention
Insulin resistance (measured by euglycemic insulin clamp glucose disposal rate, 2-hour glucose value of oral glucose tolerance test, fasting serum proinsulin level) and obesity (body mass index, waist circumference)
O
Outcome
First hospitalization for heart failurehard clinical
Insulin resistance independently predicts the incidence of congestive heart failure in elderly men and appears to largely mediate the association between obesity and heart failure.
Cite This Study
Ingelsson et al. (2005) studied this question.