Key result
Intracoronary hyaluronidase treatment increased reactive hyperemia conductance by 43% (P<0.01), making it 93% of adenosine-induced hyperemia, demonstrating adenosine insensitivity to the glycocalyx.
Why the study?
Does intracoronary hyaluronidase treatment increase reactive hyperemia compared to adenosine-induced hyperemia in dog hearts?
Does intracoronary hyaluronidase treatment increase reactive hyperemia compared to adenosine-induced hyperemia in dog hearts?
p-value: p=<0.01
Adenosine-induced coronary hyperemia profoundly exceeds reactive hyperemia, but this difference is virtually abolished by selective removal of the glycocalyx, indicating adenosine hyperemia is insensitive to glycocalyx modification.
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Hyaluronidase may equalize reactive and adenosine hyperemia in dogs; hypothesis-generating for glycocalyx effects and should not yet change clinical adenosine use.
VanTeeffelen et al. (2005) studied Coronary hyperemia (animal model) (n=11). Intracoronary hyaluronidase vs. Heat-inactivated hyaluronidase was evaluated on Coronary conductance during reactive hyperemia (RH) vs adenosine-induced hyperemia (AH) (p=<0.01). Intracoronary hyaluronidase treatment increased reactive hyperemia conductance by 43% (P<0.01), making it 93% of adenosine-induced hyperemia, demonstrating adenosine insensitivity to the glycocalyx.
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