January 1, 1994Journal of Cardiovascular Pharmacology
Antihypertensive Therapy and Progression of Diabetic Renal Disease
Key result
ACE inhibitors and heart-rate-lowering calcium antagonists attenuate the progression of diabetic renal disease to a greater extent than dihydropyridines and most other antihypertensive agents.
Why the study?
Does antihypertensive therapy with ACE inhibitors or heart-rate-lowering calcium antagonists reduce the progression of diabetic renal disease compared to other agents?
Population
Diabetic patients with renal insufficiency and animal models of diabetes
Comparison
Antihypertensive therapy vs Other antihypertensive agents
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May support ACE inhibitors or rate-lowering CCBs for diabetic nephropathy; leaves open need for confirmatory RCTs.
Structured PICO
Does antihypertensive therapy with ACE inhibitors or heart-rate-lowering calcium antagonists reduce the progression of diabetic renal disease compared to other agents?
P
Population
Diabetic patients with renal insufficiency and animal models of diabetes
I
Intervention
Antihypertensive therapy (ACE inhibitors, heart-rate-lowering calcium antagonists like diltiazem and verapamil, and dihydropyridine calcium antagonists)
C
Comparator
Other antihypertensive agents
O
Outcome
Progression of diabetic renal disease (intraglomerular pressure/volume, mesangial matrix expansion, albuminuria, glomerulosclerosis)surrogate
ACE inhibitors and non-dihydropyridine calcium antagonists offer superior renoprotection in diabetic nephropathy compared to dihydropyridine calcium antagonists.
Cite This Study
Hoelscher et al. (1994) conducted a review in Diabetic renal disease. ACE inhibitors and heart-rate-lowering calcium antagonists vs. Other antihypertensive agents was evaluated on Progression of diabetic renal disease. ACE inhibitors and heart-rate-lowering calcium antagonists attenuate the progression of diabetic renal disease to a greater extent than dihydropyridines and most other antihypertensive agents.