January 1, 1995The Journal of Clinical Pharmacology
Hypertension in Diabetic Patients: An Update of Interventional Studies to Preserve Renal Function
Why the study?
Do converting enzyme inhibitors and nondihydropyridine calcium antagonists reduce progressive renal injury independent of blood pressure reduction in hypertensive diabetic patients?
Population
Hypertensive patients with Type I or Type II diabetes mellitus
Design
Review
Authors
Discussion
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Implication
May support BP-independent renoprotection with ACE inhibitors in diabetic nephropathy; leaves open confirmation in prospective trials.
Structured PICO
Do converting enzyme inhibitors and nondihydropyridine calcium antagonists reduce progressive renal injury independent of blood pressure reduction in hypertensive diabetic patients?
P
Population
Hypertensive patients with Type I or Type II diabetes mellitus
I
Intervention
Antihypertensive agents, specifically converting enzyme inhibitors and nondihydropyridine calcium antagonists
O
Outcome
Progression of diabetic renal disease and proteinuria
Converting enzyme inhibitors and nondihydropyridine calcium antagonists may offer renoprotective effects independent of blood pressure lowering in hypertensive diabetic patients.
Cite This Study
Hoelscher et al. (1995) studied this question.