April 1, 1993American Journal of Hypertension
Hypertension in Diabetic Patients An Overview of Interventional Studies to Preserve Renal Function
Why the study?
Do antihypertensive agents (ACE inhibitors, verapamil, diltiazem) preserve renal function in diabetic patients with hypertension or microalbuminuria?
Population
Diabetic patients with hypertension or microalbuminuria
Design
Review
Authors
Discussion
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Implication
May support preferential use of ACE inhibitors, verapamil, or diltiazem in hypertensive diabetes; leaves open confirmation by long-term randomized trials.
Key Points
- This review aims to summarize interventional studies focused on preserving renal function in diabetic patients with hypertension.
- Examined various animal and human studies on the impact of diabetes and hypertension on renal function.
- Evaluated specific antihypertensive therapies, including ACE inhibitors, verapamil, and diltiazem.
- Highlighted the role of blood pressure control in preventing renal failure.
- Certain antihypertensive medications have renal and vascular benefits for diabetic patients with hypertension.
- Not all diabetic patients will experience progressive renal disorders, but those with hypertension or microalbuminuria are at greater risk.
- Long-term studies are essential to confirm the benefits of these interventions.
Structured PICO
Do antihypertensive agents (ACE inhibitors, verapamil, diltiazem) preserve renal function in diabetic patients with hypertension or microalbuminuria?
P
Population
Diabetic patients with hypertension or microalbuminuria
I
Intervention
Antihypertensive agents (specifically angiotensin converting enzyme inhibitors, verapamil, and diltiazem)
O
Outcome
Preservation of renal function
ACE inhibitors and non-dihydropyridine calcium channel blockers (verapamil, diltiazem) appear beneficial for preserving renal function in hypertensive diabetic patients.
Limitations
- Long-term studies are needed to consolidate these findings
Cite This Study
George L. Bakris (1993) studied this question.