The presence of right heart thrombi in patients with pulmonary embolism was associated with significantly higher all-cause mortality at 30 days (adjusted OR 2.50; 95% CI 1.62-3.84; p<0.001).
Cohort (n=12,441)
Does the presence of right heart thrombi increase mortality and recurrences in patients with pulmonary embolism?
The presence of right heart thrombi in patients with pulmonary embolism is relatively infrequent but is associated with significantly increased risks of all-cause and PE-related mortality at 30 days.
Estimación del efecto: adjusted OR 2.50 (95% CI 1.62-3.84)
valor p: p=<0.001
There is a lack of comprehensive data on the prevalence, predictors and prognostic significance of right heart thrombi (RHT) in pulmonary embolism.In this study of patients with pulmonary embolism from the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry, we assessed the prevalence and predictors of RHT, and the association between the presence of RHT and the outcomes of all-cause mortality, pulmonary embolism-related mortality, recurrences, and major bleeding through 30 days after initiation of pulmonary embolism treatment.Of 12 441 patients with pulmonary embolism and baseline echocardiographic data, 2.6% had RHT. The following increased the risk of RHT: younger age, previous bleeding, congestive heart failure, cancer, syncope, systolic blood pressure <100 mmHg, and arterial oxyhaemoglobin saturation <90%. Patients with RHT were significantly more likely to die from any cause (adjusted OR 2.50 (95% CI 1.62-3.84); p<0.001) and from pulmonary embolism (adjusted OR 4.29 (95% CI 2.45-7.48); p<0.001) during follow-up. RHT was associated with an increased risk of recurrence during follow-up (1.8% versus 0.7%; p=0.04). Major bleeding was similar in patients with and without RHT.In patients presenting with pulmonary embolism, RHT is relatively infrequent. Patients with RHT had a worse outcome when compared with those without RHT.
Barrios et al. (Thu,) conducted a cohort in Pulmonary embolism (n=12,441). Presence of right heart thrombi (RHT) vs. Absence of right heart thrombi was evaluated on All-cause mortality (adjusted OR 2.50, 95% CI 1.62-3.84, p=<0.001). The presence of right heart thrombi in patients with pulmonary embolism was associated with significantly higher all-cause mortality at 30 days (adjusted OR 2.50; 95% CI 1.62-3.84; p<0.001).