Key result
Cardiac autonomic denervation plus pulmonary vein isolation significantly increased freedom from atrial fibrillation compared to PVI alone (OR 1.85; 95% CI 1.33-2.59; P=0.29).
Why the study?
Does adjunctive cardiac autonomic denervation (CFAE/GP ablation) plus PVI improve freedom from AF recurrence compared to PVI alone in patients with atrial fibrillation?
Population
1,147 patients with atrial fibrillation (paroxysmal and nonparoxysmal) pooled from 15 controlled trials
Comparison
Adjunctive cardiac autonomic denervation via… vs Pulmonary vein isolation (PVI) alone
Design
Meta-analysis
Authors
Loading...
Supports adjunctive cardiac autonomic denervation with PVI for greater AF freedom; confirms benefit across pooled trial data.
Meta-Analysis (n=1,147)
Does adjunctive cardiac autonomic denervation (CFAE/GP ablation) plus PVI improve freedom from AF recurrence compared to PVI alone in patients with atrial fibrillation?
Effect estimate: OR 1.85 (95% CI 1.33-2.59)
p-value: p=0.29
Adjunctive cardiac autonomic denervation combined with PVI improves freedom from AF recurrence compared to PVI alone, but is not effective as a standalone strategy.
ZHANG et al. (2012) conducted a meta-analysis in Atrial Fibrillation (n=1,147). Cardiac autonomic denervation (CAD) plus pulmonary vein isolation (PVI) vs. PVI alone was evaluated on Freedom from AF/ATs (OR 1.85, 95% CI 1.33-2.59, p=0.29). Cardiac autonomic denervation plus pulmonary vein isolation significantly increased freedom from atrial fibrillation compared to PVI alone (OR 1.85; 95% CI 1.33-2.59; P=0.29).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: