Key result
Anatomic ganglionated plexi ablation resulted in a significantly lower rate of freedom from atrial tachyarrhythmia compared to circumferential pulmonary vein isolation (34.3% vs 65.7%, P=0.008).
Why the study?
Does anatomic ganglionated plexi ablation improve freedom from atrial tachyarrhythmia compared to circumferential pulmonary vein isolation in patients with paroxysmal atrial fibrillation?
Cohort (n=70)
Does anatomic ganglionated plexi ablation improve freedom from atrial tachyarrhythmia compared to circumferential pulmonary vein isolation in patients with paroxysmal atrial fibrillation?
Effect estimate: HR 2.08 (95% CI 1.03-4.22)
Absolute Event Rate: 34.3% vs 65.7%
p-value: p=0.008
Anatomic ganglionated plexi ablation yields a significantly lower long-term success rate for maintaining sinus rhythm compared to standard circumferential pulmonary vein isolation in patients with paroxysmal atrial fibrillation.
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Anatomic GP ablation was associated with lower arrhythmia freedom than CPVI; challenges its use and leaves open optimal strategies for paroxysmal AF.
Mikhaylov et al. (2010) conducted a cohort in paroxysmal atrial fibrillation (n=70). anatomic ganglionated plexi (GP) ablation vs. circumferential pulmonary vein isolation (CPVI) was evaluated on freedom from any atrial tachyarrhythmia without antiarrhythmics (HR 2.08, 95% CI 1.03-4.22, p=0.008). Anatomic ganglionated plexi ablation resulted in a significantly lower rate of freedom from atrial tachyarrhythmia compared to circumferential pulmonary vein isolation (34.3% vs 65.7%, P=0.008).
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