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December 13, 1977Biochemistry

Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids

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Population

In vitro angiotensin-converting enzyme (ACE)

Design

Preclinical

Authors

DCDavid W. CushmanPortland State UniversityHCH.S. CheungThe Honourable Society of Lincoln's InnESEmily F. SaboTulane University

Discussion

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Implication

May guide preclinical ACE inhibitor design; leaves open clinical translation in cardiovascular disease.

Structured PICO

P
Population
In vitro angiotensin-converting enzyme (ACE)
I
Intervention
Carboxyalkanoyl and mercaptoalkanoyl amino acids
O
Outcome
ACE inhibitionsurrogate

Describes the biochemical design of carboxyalkanoyl and mercaptoalkanoyl amino acids as potent competitive inhibitors of angiotensin-converting enzyme.

Cite This Study

Cushman et al. (1977) studied this question.

synapsesocial.com/papers/6a158f699b87f33fc69fa9c3https://doi.org/10.1021/bi00644a014
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