What question did this study set out to answer?

Determine the functional significance of free amino groups in proteins that inhibit proteolytic enzymes.

February 1, 1967Biochemistry

Modification of Amino Groups in Inhibitors of Proteolytic Enzymes*

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Authors

RHRoyce HaynesUniversity of Washington DODavid T. OsugaUniversity of California, Davis RFRobert E. FeeneyUniversity of South Florida

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Implication

Biochemical investigation demonstrates the functional impact of modifying amino groups in protease inhibitors, suggesting critical structural roles for specific residues.

Key Points

Determine the functional significance of free amino groups in proteins that inhibit proteolytic enzymes.
Subjected proteolytic enzyme inhibitors to chemical modification targeting functional amino groups.
Assayed the retention or loss of inhibitory activity toward target proteases following amino group modification.
Chemical modification of key amino residues alters the inhibitory capacity of protease inhibitors.
Specific intact amino groups are required to maintain effective binding and inhibition of proteolytic enzymes.

Cite This Study

Haynes et al. (1967) studied this question.

synapsesocial.com/papers/6a6fc70222b3175134db47d2 https://doi.org/10.1021/bi00854a023

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Implication

Biochemical investigation demonstrates the functional impact of modifying amino groups in protease inhibitors, suggesting critical structural roles for specific residues.

Modification of Amino Groups in Inhibitors of Proteolytic Enzymes*

Discussion

Member takes

Implication

Key Points

Cite This Study

Modification of Amino Groups in Inhibitors of Proteolytic Enzymes*

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider