Key result
Higher epicardial adiponectin expression linked to ~25% lower odds of multivascular lesions in CAD.
Why the study?
Although adipocytokine content in heart fat depots is altered in CAD, whether these changes associate with the degree of coronary artery atherosclerotic damage remained unestablished.
Does the degree of coronary artery atherosclerosis correlate with altered expression of adipocytokines in heart fat depots in patients with CAD?
Observational (n=119)
No
Does the degree of coronary artery atherosclerosis correlate with altered expression of adipocytokines in heart fat depots in patients with CAD?
Effect estimate: OR 0.753 (95% CI 0.650-0.985)
p-value: p=<0.001
The severity of coronary artery atherosclerosis is associated with a pro-inflammatory shift in the adipocytokine profile of epicardial and perivascular adipose tissue, suggesting a local paracrine role in CAD progression.
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Hypothesis-generating for epicardial adiponectin in multivessel CAD; prospective studies needed before clinical consideration.
Груздева et al. (2021) conducted an observational in Coronary artery disease (n=119). Coronary artery disease vs. Patients without coronary artery disease was evaluated on Predictors of multivascular lesions in CAD (decrease in ADIPOQ expression in epicardial adipose tissue) (OR 0.753, 95% CI 0.650-0.985, p=<0.001). In patients with coronary artery disease, decreased expression of adiponectin in epicardial adipose tissue was a significant predictor of multivascular lesions (OR 0.753).
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