Key result
Coronary artery disease was associated with more pronounced pro-inflammatory changes, including lower adiponectin and higher leptin and IL-6 in epicardial adipocytes, compared to heart defects.
Why the study?
Epicardial and perivascular fat depots synthesize biologically active adipocytokines that affect inflammation, fibrosis, and atherogenesis, but their expression and secretion profiles in coronary artery disease versus valvular disease required assessment.
Does the expression and secretion of adipocytokines in epicardial and perivascular adipose tissue differ between patients with coronary artery disease and those with valvular heart defects?
Observational (n=134)
Does the expression and secretion of adipocytokines in epicardial and perivascular adipose tissue differ between patients with coronary artery disease and those with valvular heart defects?
Epicardial and perivascular adipose tissues in patients with coronary artery disease exhibit a pronounced pro-inflammatory adipocytokine profile, supporting their pathogenetic role in atherogenesis.
Does not support practice change; leaves open whether epicardial adipokine modulation affects CAD outcomes.
Adipose tissue (AT) is an endocrine and paracrine organ that synthesizes biologically active adipocytokines, which affect inflammation, fibrosis, and atherogenesis. Epicardial and perivascular fat depots are of great interest to researchers, owing to their potential effects on the myocardium and blood vessels. The aim of the study was to assess the expression and secretion of adipocytokine genes in the AT of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. This study included 84 patients with CAD and 50 patients with aortic or mitral valve replacement. Adipocytes were isolated from subcutaneous, epicardial (EAT), and perivascular AT (PVAT), and were cultured for 24 h. EAT exhibited the lowest level of adiponectin gene expression and secretion, regardless of nosology, and high expression levels of the leptin gene and interleukin-6 (IL-6). However, EAT adipocytes in patients with CAD were characterized by more pronounced changes in comparison with the group with heart defects. High leptin and IL-6 levels resulted in increased pro-inflammatory activity, as observed in both EAT and PVAT adipocytes, especially in individuals with CAD. Therefore, our results revealed the pathogenetic significance of alterations in the adipokine and cytokine status of adipocytes of EAT and PVAT in patients with CAD.
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Груздева et al. (2022) conducted an observational in Coronary artery disease (n=134). Coronary artery disease vs. Aortic or mitral valve replacement was evaluated on Expression and secretion of adipocytokine genes in adipose tissue. Coronary artery disease was associated with more pronounced pro-inflammatory changes, including lower adiponectin and higher leptin and IL-6 in epicardial adipocytes, compared to heart defects.
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