Key result
Computer simulation of fibroblast-myocyte coupling showed that weak coupling (<0.25 nS) increased conduction velocity by up to 5%, while stronger coupling slowed conduction and prolonged action potential duration by 0-80 ms.
Population
Two-dimensional microstructure tissue model representing a monolayer culture of cardiac cells covered by a…
Comparison
Varying fibroblast resting potential, density… vs Control (baseline state without coupling effects)
Design
Preclinical
Authors
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May modulate conduction in fibrotic tissue; leaves open in vivo relevance for arrhythmia risk.
Computer simulations demonstrate that the strength of electrical coupling between fibroblasts and myocytes significantly alters conduction velocity, upstroke velocity, and action potential duration in a coupling-dependent manner.
Jacquemet et al. (2008) studied Myocardium electrophysiology. Fibroblast-myocyte coupling vs. Control (no coupling or varying coupling strengths) was evaluated on Conduction velocity, upstroke velocity, and action potential duration. Computer simulation of fibroblast-myocyte coupling showed that weak coupling (<0.25 nS) increased conduction velocity by up to 5%, while stronger coupling slowed conduction and prolonged action potential duration by 0-80 ms.
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